Toddalia aculeata Pers

In 1839, after isolation from Ch. majus, chelerythrine (2) was described by Probst as an alkaloid yielding red salts (from Greek erythros, red) [24,24]. In fact, it was a mixture with sanguinarine [26]. The pure alkaloid was isolated by Konig, who left it the original name, chelerythrine, in spite of the bright yellow colour of its salts [26], The alkaloid toddaline, isolated from Toddalia aculeata Pers. [27], was later proved to be identical with chelerythrine [28,29]. 

Recently, 6-hydroxydihydrosanguinarine (34) has been reported as a new alkaloid isolated from Dactylicapnos torulosa Hook f et Thoms. [125,126]. The compound is described as an amorphous solid of yellow colour, however, the substance e diibits major discrepancies in ipectral data with the structure given [127]. 6-Hydroxydihydrochelerythrine has allegedly been isolated from Toddalia aculeata Pers. in the form of its acetic acid ester [128], However, its H NMR data are not in agreement with those previously published for this compound [129]. Universally, 6-hydroxydihydroderivatrves (pseudobases) are unstable semiaminoacetals with basic character which cannot occur in acidic plant tissues at all and could not be isolated as natural products especially after 5% HCl has been used in the isolation procedure cf. 125,128]. 

Nitidine and garonine are known as potential anti-tumour, antileukemic, and antiviral agents [9,52,98]. Some synthetic 12-alkoxyderivatives of 2,3,8,9-tetramethoxy QBA are potent in vitro inhibitors of the growth of P388 cells [144]. Nitidine, isolated firom Kenyan Toddalia aculeata Pers. (synonym T. asiatica (L.) Lamk.) has shown antimalarial activity [145]. Nitidine and fagaronine have been foimd to inhibit HTV reverse transcriptase [146]. 

Combes, G., R. Pernet, and R. Pierre Sur I isolement, la structure et les proprietes d une nouvelle coumarine extraite de Toddalia aculeata Pers. Bull. Soc. chim. France 1961, 1609. 

Toddalia aculeata (Toddalia asiatica) is a trae gi owing wild in the Nilgiri mountains, and is also found in the Philippine Islands. It is known as the wild orange tree. The leaves yield 0 08 per cent, of essential oil, which, according to Brooks, has an odour of camphor and lemon-grass. Its characters are as follows —... 

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