Toddalia

Toddalia asiatica (Rutaceae) phy 48,1377 98 Xylopia vieillardi (Annonaceae) jnp 54,466 91... 

Toddalia asiatica Lamk. (Rutaceae) provided a low yield of toddalidimerine (352), the first bisbenzophenanthridine alkaloid having dissimilar subunits. It... 

Coehcline (Annonaceae), Berberis, Hydrastis, Mahonia, Nandina (Berberidaceae), Archangelica (Menispermaceae), Argemtme, Chelidtmium, Corydalis (Papaveraceae), Coptis, Thalidrum (Ranunculacae), Evodia, Phelhdendron, Toddalia,... 

Herberts vulgaris, B. sp., Hydrastis canadensis, Mahonia sp., Mindina sp. (Berberidaceae), Archangelica sp. (Menispermaceae), Argemone sp., Chelidonium sp., Corydalis sp. (Papaveraceae), Coptis sp., Thalictrum sp. (Ranunculaceae), Evodia sp., Toddalia sp., gfinthoxylum sp. (Rutaceae)... 

Tsai, I. L. Wun, M. F. Teng, C. M. Ishikawa, T. Chen, I. S. Anti-platelet aggregation constituents from Formosan Toddalia asiatica. Phytochem., 1998, 48 1377-1382. 

In 1839, after isolation from Ch. majus, chelerythrine (2) was described by Probst as an alkaloid yielding red salts (from Greek erythros, red) [24,24]. In fact, it was a mixture with sanguinarine [26]. The pure alkaloid was isolated by Konig, who left it the original name, chelerythrine, in spite of the bright yellow colour of its salts [26], The alkaloid toddaline, isolated from Toddalia aculeata Pers. [27], was later proved to be identical with chelerythrine [28,29]. 

Recently, 6-hydroxydihydrosanguinarine (34) has been reported as a new alkaloid isolated from Dactylicapnos torulosa Hook f et Thoms. [125,126]. The compound is described as an amorphous solid of yellow colour, however, the substance e diibits major discrepancies in ipectral data with the structure given [127]. 6-Hydroxydihydrochelerythrine has allegedly been isolated from Toddalia aculeata Pers. in the form of its acetic acid ester [128], However, its H NMR data are not in agreement with those previously published for this compound [129]. Universally, 6-hydroxydihydroderivatrves (pseudobases) are unstable semiaminoacetals with basic character which cannot occur in acidic plant tissues at all and could not be isolated as natural products especially after 5% HCl has been used in the isolation procedure cf. 125,128]. 

Nitidine and garonine are known as potential anti-tumour, antileukemic, and antiviral agents [9,52,98]. Some synthetic 12-alkoxyderivatives of 2,3,8,9-tetramethoxy QBA are potent in vitro inhibitors of the growth of P388 cells [144]. Nitidine, isolated firom Kenyan Toddalia aculeata Pers. (synonym T. asiatica (L.) Lamk.) has shown antimalarial activity [145]. Nitidine and fagaronine have been foimd to inhibit HTV reverse transcriptase [146]. 

Diotamnine Afraegle, Boronella, Dutaillyea, Esenbeckia, Flindersia, Glycosmis,Haplophyllum, Melicope, Myrtopsis Toddalia, Zanthoxylum ... 

Flindersia, Glycostnis, Haplophyllum, , , Melicope, < > Monnieria,Murraya, Myrtopsis, Orlcia, Teclea, Toddalia, Tylophora, Vespris, Zanthoxylum . 

Y-Fagarine Aegle, °° Dlctamnus, Erythrochiton, Flinders la, Haplophyllum, 2, Honnieria, ° Myrtopsis, " Toddalia, Tylophora," Vespris, Zanthoxylum ... 

Source Toddalia asiatica. Biological activity Anti AIDS. 

Micromelum ceylanicum Swingle Murraya paniculata (L.) Jack Paramignya monophylla Wight Toddalia asiatica (L.) Lam. 

Isolated from the plant genera Toddalia and Zanthoxylum. 

Besides the benzophenanthridine bases having oxygen constituents at the C-3 and C-4 atoms, some bases having oxygen substituents in the positions C-2 and C-3 (alkaloids nitidine, oxynitidine, and avicine) could be isolated from the plant genera Toddalia and Zanthoxylum (Rutaceae). Sanguinarine and similar bases have recently been synthesized by Dyke et al. (134a-c). 

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