TNF-a inhibition

Vascular Endothelial Growth Inhibitor (Protein sharing homology with TNF-a) Inhibits EC proliferation... 

Moreland, L. and Emery, P. (eds). 2003. TNF-a Inhibition in the Treatment of Rheumatoid Arthritis. Taylor and Francis, London. 

Another effect of LPS may be the inhibition of tumor angiogenesis. This was evidenced in melanoma B16- bearing C57BL/6 mice treated i.v. with the lipid A GL-60, after an IFN-y injection [114], It was confirmed in the same model using DT-5461 alone injected i.v. [94]. This effect of LPS is likely to be due to the production of TNF-a. This cytokine may be toxic for the endothelium [64], inhibiting at the same time the motility and proliferation of endothelial cells [59]. Sato et al. [115] showed that TNF-a inhibits tumor-induced angiogenesis in a rabbit corneal pocket assay. On the contrary, Vukanovic and Isaacs [116] concluded that TNF-... 

Fig. 12.9 Correlation between carbon number of the hydrocarbon group in mono- and bis-acyl and TNF-a inhibition in human blood (top) and NO inhibition in murine J774A.1 cells (bottom)...

Park E, Kalunta Cl, Nguyen TT, et al. TNF-a inhibits anti-IgM-mediated apoptosis in Ramos cells. Exp Cell Res 1996 226 1-10. 

Studies using human adipose tissue have now shown that TNF-a inhibits LPL activity by down-regulating its protein expression [388]. Increased TNF-a mRNA levels are correlated wifh decreased LPL activity in human subcutaneous adipose tissue [393]. In addition, TNF-a reduces the expression of FA transporters in adi-... 

T-144 Thalidomide Selectively inhibits biosynthesis of tumor necrosis factor a (TNF-a) inhibits angiogenesis. DNA Intercalators/Crosslinkers ... 

Although mesalamine is a salicylate, its therapeutic effect does not appear to be related to cyclooxygenase inhibition indeed, traditional nonsteroidal antiinflammatory drugs actually may exacerbate IBD. Many potential sites of action have been demonstrated in vitro for either sulfasalazine or mesalamine inhibition of the production of IL-1 and TNF-a, inhibition of the lipoxygenase pathway, scavenging of free radicals and oxidants, and inhibition of NF-Kp, a transcription factor pivotal to production of inflammatory mediators. Specific mechanisms of action of these drugs have not been identified. 

ISIS 104838 is a tumor necrosis factor-a (TNF-a) inhibiting second-generation ON containing five 2 -0-(2-methoxyethyl) modified (2 -MOE) nucleosides at the 3 - and 5 -terminus, respectively. The pharmacokinetic pattern for this second-generation PON was similar to first-generation PONs, except for a less pronounced nonlinearity in systemic exposure and a substantially prolonged terminal half-life of 27 3.8 days, most likely due to the complete blockade of exonuclease digestion by the MOE modification [67]. 

TNF-a converting enzyme (TACE) is a newly discovered enzyme in the disintegrin and metalloproteinase (ADAM) family (78). This enzyme releases the 17-kD mature TNF-a fiom membrane-bound TNF-a by cleaving Ala 76 and Val 77 linkage. TACE has also been shown to be involved with other cell surface protein shedding events such as the p55 and p75 TNF-a receptors (79). Our laboratory has previously shown that acute administration of alcohol (EtOH)to rats suppresses TNF-a production posttranscriptionally in the lung and blood (20,80). Recently, we have further defined the mechanism of TNF-a inhibition by EtOH, which revealed... 

---