Tissue transplantation autografts

Fig. 16 H E staining of (a) normal skin tissue and (b-d) sections of wounds after treatment with BDEs loaded with TMC/pDNA-VEGF for 10 days, followed by transplantation of ultrathin autografts for 21 days (b), 70 days (c) and 112 days (d). Scale bar 200 pm [187]...

Autografts are bone tissue harvested from a donor site within the same individual (typically from the iliac crest of the pelvis) and transplanted to the fracture site. The innately autologous nature of these scaffolds combined with their highly osteoinductive properties has led them to be considered the gold standard . However, while they are useful for providing a filler material that is conducive to bone regeneration without any risk of rejection, material is limited and the removal of bone from the donor site often results in residual pain and morbidity [28]. 

Y. Hirano, K. Omura, H. Yoshiba, N. Ohta, C. Hiranuma, K. Nitta, Y. Nishida, and G. Watanabe, Near-Infrared Spectroscopy for Assessment of Tissue Oxygen Saturation of Transplanted Jejunal Autografts in Cervical Esophageal Reconstruction, Surg. Today, 35(1), 67 (2005). 

An emergency operation was performed and consisted of esophagostomy, gastrostomy, and stripping of the esophagus. Three weeks after admission, we performed excision of necrotic tissue (Fig. 4.97) and mesh-autograft transplantation, and the wound healed adequately within 8 days (Fig. 4.98). At this time (3 weeks after admission) the facial lesions are completely healed (Fig. 4.99). 

Autografting is a class of method in which bone tissue is transplanted from one site to another site of the same individual. The concept is basically the patient s own bone collected from a donor site and transplanted to another site of the same body that requires bone regeneration. It is commonly harvested from the patient s iliac crest in the form of cancellous bone. Mowlem clinically proved it in 1944 [27], and he had successfully treated about 75 critical cases using cancellous bone from the... 

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