Tissue interaction analysis types

Dealing with this type of multiparameter correlation analysis, a series of twelve articles entitled Solubility Properties in Polymers and Biological Media was published by Kamlet, Taft, Abraham et al. (Part 1 [273]...Part 12 [274]), as well as another series entitled Solute Solvent Interactions in Chemical and Biological Systems (Part 4 [358]... Part 7 [359]). The application of the LSER equation (7-58) to the prediction of solubilities of organic nonelectrolytes in water, blood, and other body tissues has been reviewed [286],... 

One of the most crucial considerations in proteomic analysis is sample preparation because this will ultimately dictate the number and type of proteins that can be processed. The first priority is to establish the precise protein system to be studied [e.g., will this be a comprehensive and exhaustive catalogue of every expressed protein within a tissue or cellular extract, or is only a small subset of a cellular proteome (e.g., only phosphoproteins or membrane-bound proteins) sufficient for analysis ]. Whether a full or partial proteome, or even a limited number of specific proteins is required for analysis, it is crucial that the extraction technique provide maximal protein recovery while preserving the integrity of the protein complex to be examined. Furthermore, the method of preparation must be totally compatible with the separation methods to be used. This is particularly important for separation technologies that are reliant on protein-protein interactions or drug/ligand/antibody, etc. interactions. Poor recovery of proteins is clearly... 

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