Tissue engineering trachea

K. Kojima, L.J. Bonassar, A.K. Roy, H. Mizuno, J. Cortiella, C.A. Vacanti, A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cells, FASEB J. 17 (8) (May 2003) 823-828. 

In the lung, tissue engineering strategies have been employed to engineer larger airway structures such as the trachea, main stem bronchi, and bronchiole. In 2008, the first transplantation of a tissue-engineered trachea in a human being... 

Shi, H., Wang, W., Lu, D., et al., 2012. Cellular biocompatibility and biomechanical properties of N-carboxyethylchitosan/nanohydroxyapatite composites for tissue-engineered trachea. Artificial Cells, Blood Substitutes and Biotechnology 40 (1-2), 120-124. 

Kanzaki M, Yamato M, Hatakeyama H et al (2006) Tissue engineered epithelial cell sheets for the creation of a bioartificial trachea. Tissue Eng 12 1275-1283 Kiick KL (2008) Peptide- and protein-mediated assembly of heparinized hydrogels. Soft Matter 4 29-37... 

B.H.I. Ruszymah, K. Chua, M.A. Latif, F.N. Hussein, A. Bin Saim, Formation of in vivo tissue engineered human hyaline cartilage in the shape of a trachea with internal support, Int. J. Pediatr. Otorhinolaryngol. 69 (11) (November 2005) 1489—1495. 

K. Omori, Y. Tada, T. Suzuki, Y. Nomoto, T. Matsuzuka, K. Kobayashi, T. Nakamura, S. Kanemaru, M. Yamashita, R. Asato, Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea, Ann. Otol. Rhinol. Laryngol. 117 (9) (September 2008) 673—678. 

K. Omori, J. Ito, A tissue-engineering approach for stenosis of the trachea and/or cricoid, Acta Otolaryngol. Suppl. (563) (November 2010) 79—83. 

While hydrogels or sponges have been examined for cell transplant for the parenchyma of the hver or lung, more traditional tissue engineering approaches have been utilized for some of the larger stmctures such as bile ducts, trachea, or bronchioles. These traditional tissue engineering approaches utilize scaffold materials made from naturaUy-derived and/or synthetic polymers and have been implanted with some success in vivo in both humans and in animal models. 

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