Tissue engineering chitosan-based hydrogels

Y. Zhou, G. Ma, S. Shi, D. Yang, J. Nie, Photopolymerized water-soluble chitosan-based hydrogel as potential use in tissue engineering, Int. J. Biol. Macromol. 48 (2011) 408-413. 

Jin R, McHcira Terxeira LS, Dijkstra PJ, Karperien M, van Blitterswijk CA, Zhong ZY, Feijen J (2009) Injectable chitosan-based hydrogels for cartilage tissue engineering. Biomaterials 30 2544-2551... 

In addition to PEG-based chitosan composites, temperature-sensitive chitosan composites have also been developed for tissue engineering applications by grafting of pluronics onto chitosan. This composite material formed a thermosensitive hydrogel that exhibited a transition temperature of 30-35°C when the grafting percentage was altered (Chung et al, 2005b). These thermosensitive... 

Tan, H., Chu, C. R., Payne, K. A. Marra, K. G. (2009a) Injectable in to-forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials, 30, 2499-506. 

By using microgels with well-defined properties as building blocks, macroscale hydrogels with unique spatial properties, such as gradients in mechanical and/or biomolecular characteristics, may be built from the bottom up. Microsphere-based scaffolds additionally offer 3D pore interconnectivity and desirable pore size. For instance, chitosan microsphere scaffolds have been produced for cartilage and osteochondral tissue engineering [81]. 

Gamica-Palafox, I.M., Sanchez-Arevalo, F.M., Velasquillo, C., Garcia-Carvajal, Z.Y, Garcia-Lopez, J, Ortega-Sanchez, C. et al (2014) Mechanical and structural response of a hybrid hydrogel based on chitosan and poly(vinyl alcohol) cross-linked with epichlorohydrin for potential use in tissue engineering. 

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