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Tirilazad mesylate

The RANTTAS Investigators. A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke 1996 27 447-453. [Pg.114]

Sato, P.H. and Hall, E.D. (1992). Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfasion injury. J. Neurochem. 58, 2263-2268. [Pg.261]

Table 3. Hospital costs of tirilazad mesylate for subarachnoid hemorrhage in men... Table 3. Hospital costs of tirilazad mesylate for subarachnoid hemorrhage in men...
Ghck H, Wihke R, Polsky D, Liana T, Alves WM, Kasseh N, Schulman KA. Economic analysis of tirilazad mesylate for aneurysmal subarachnoid hemorrhage economic evaluation of a phase IB clinical trial in Eu-... [Pg.53]

Fig. 9.6 Chemical structures of antioxidants in phase III clinical trials. Tirilazad mesylate (a) ... Fig. 9.6 Chemical structures of antioxidants in phase III clinical trials. Tirilazad mesylate (a) ...
The STIPAS Investigators (1994). Safety study of tirilazad mesylate in patients with acute ischemic stroke (STIPAS). Stroke 25 418 423. [Pg.259]

Subsequently, it was found that the substitution of a complex amine on the non-glucocorticoid steroid nucleus in place of the 21-hydroxyl functionality results in a dramatic enhancement of the lipid antioxidant activity. Many of these 21-aminosteroid compounds effectively inhibit iron-catalyzed lipid peroxidation in rat-brain tissue homogenates under assay conditions where the glucocorticoid steroid methylprednisolone and the non-glucocorticoid analog U-72099E are completely ineffective [20,21]. Of these, U-74006F (tirilazad mesylate Fig. 2) has shown excellent activity in experimental models of spinal-cord and brain injury. [Pg.221]

TIRILAZAD MESYLATE IN CAT SPINAL CORD COMPRESSION INJURY... [Pg.228]

Anderson, D.K., Hall, E.D., Braughler, J.M., McCall, J.M. and Means, E.D. (1991) Effect of delayed administration of U74006F (tirilazad mesylate) on recovery of locomotor function following experimental spinal cord injury, J. Neurotrauma 8, 187-192. [Pg.237]

Tirilazad mesylate Pharmacia Upjohn Subarachnoid haemorrhage... [Pg.849]

Eleishaker JC, Hulst-Pearson LK, Peters GR. Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects. Am J Ther 1995 2 553-560. [Pg.336]

Bracken MB, Shepard Ml, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL, Jr., Piepmeier J, Sonntag VK, Wagner F, Wilberger JE, Winn HR, Young W (1997) Administration of meth-ylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277 1597-1604. [Pg.627]

Marshall LF, Maas Al, Marshall SB, et al. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg 1998 89 519-525. [Pg.1074]

Wienkers LC, Steenwyk RC, Mizsak SA, Pearson PG. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase. Drug Metab Dispos 1995 23 383-392. [Pg.366]

Wienkers LC, Steenwyk RC, Sanders PE, Pearson PG. Biotransformation of tirilazad in human 1. C5dochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. J Pharmacol Exp Ther 1996 277 982-990. [Pg.366]

No author listed (2000) Tirilazad mesylate in acute ischemic stroke a systematic review. Irrilazad Int Steering Comm Stroke 31 2257-2265... [Pg.103]

See other pages where Tirilazad mesylate is mentioned: [Pg.995]    [Pg.99]    [Pg.80]    [Pg.268]    [Pg.269]    [Pg.269]    [Pg.275]    [Pg.314]    [Pg.599]    [Pg.621]    [Pg.600]    [Pg.623]    [Pg.226]    [Pg.234]    [Pg.382]    [Pg.447]    [Pg.475]    [Pg.9]    [Pg.76]    [Pg.102]    [Pg.156]    [Pg.161]    [Pg.161]    [Pg.174]    [Pg.221]    [Pg.241]   
See also in sourсe #XX -- [ Pg.268 ]

See also in sourсe #XX -- [ Pg.849 ]

See also in sourсe #XX -- [ Pg.849 ]

See also in sourсe #XX -- [ Pg.508 ]



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Mesylate

Mesylation

Tirilazad

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