TIPS protection with

This caveat could be circumvented with the use of triisopropylsilyl (TIPS) protecting groups (Scheme 2a,b),12 16 or when 6-deoxy glycals (devoid of the C-6 oxygen substituent) are used as substrates (Scheme 2c,d,e).13,17,18... 

We can also easily convert hydroxyl groups to silyl ethers. Section 14-10B covered the use of the triisopropylsilyl (TIPS) protecting group for alcohols. Similarly, sugars can be converted to their silyl ethers by treatment with a silyl chloride, such as chlorotrimethylsilane (TMSC1), and a tertiary amine, such as triethylamine. 

Safety pipetting aids Mouth pipeting is prohibited it is a potential source of infection either by ingestion or by inhalation. All safety pipetting aids control contamination of the suction end of the pipet and leakage from the pipet tips. Vacuum lines used to aspirate liquids are protected with liquid disinfectant traps and cartridge-type filters (0.45 pm pore size). 

A cyclohexylidene acetal can be cleaved with Py(HF), (CHCI3, 0°C, to rt, 89% yield) in the presence of the fluoride labile TIPS protective group. 

Azidodeoxy-myo-inositol 87 was efficiently protected with 2.5 and 1.2 equiv of TIPS-CI2 under conditions shown in Scheme 3-12 respectively giving the corresponding bis-disiloxane 88 and mono-disiloxane 90 in high yields respectively. These were utilized to prepare the tritium-labeled myo-inositol analogue 89 and 3-azido-3-deoxy-myo-inositol 2,4,5-trisphosphate 91. 3... 

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