Tinidazole amoebiasis

It is also used in combination with tinidazole (TINIBA DF) and metronidazole (ENTAMIZOLE) in the treatment of intestinal amoebiasis, hepatic amoebiasis and other systemic diseases due to E. histolytica. 

In practice, treatment of amoebiasis can be divided into treatment of bowel lumen amoebiasis, and tissue-invading amoebiasis. The bowel lumen infection, which is usually asymptomatic, may be in trophozoites form (non-infective) or in cysts form (infective) and treatment is directed at eradicating cysts with a luminal amoebicide (e.g. diloxanide). The tissue-invading amoebiasis (giving rise to dysentery, hepatic amoebiasis and liver abscess) must be treated with systemically active drugs (systemic amoebicides) active against trophozoites (e.g. metronidazole, tinidazole also, in dangerously ill patients dehydroemetine may be used, which is less toxic than the parent emetine (derived from ipecacuanha). Sometimes antibiotics (e.g. tetracycline) are used concurrently to stop opportunist infections. 

Nitroimidazoles were then found to have excellent anti-microbial properties. For example, tinidazole (6.16) is valued for the prophylaxis of anaerobic bacteria] infection of the bowel, before operation, particularly with species of Bacteroides, also for the treatment of such infections (Hunt et al., 1979). It is also effective in the protozoal diseases, amoebiasis, giardiasis, and trichomoniasis. For the anti-protozoaI action ofnitro-heterocycles, see Section 6.3.3. 

Schenone, H., Orfali, A. Galdamcs, M. and Rojo, M. (1975) Treatment of amoebiasis and giardiasis in children by oral administration of tinidazole, a broad spectrum antiprotozoal agent. Bol. Chil. Parasit., 30, 76. 

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