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Time-controlled pulsatile delivery

Anal, A. K. (2007),Time-controlled pulsatile delivery systems for bioactive compounds, Recent Patents Drug Deliv. Formulate 1, 73-79. [Pg.387]

This volume term also depends on p and/or k10 and overestimates the volume. However, when terminal concentration-time data are used (i.e., distribution is at steady state and elimination is the process significantly altering Cp), this volume term will produce an accurate conversion factor between Cp and the amount of drug in the body. While Vda .a overestimates the volume, it can be useful in the design of controlled release delivery systems, particularly in pulsatile delivery. [Pg.24]

Most pulsatile delivery systems are reservoir devices coated with a barrier layer. The barrier dissolves or erodes after a specified lag time, after which the drug is released rapidly from the reservoir core. In general, the lag time prior to drug release can be controlled by the thickness of the coating layer. [Pg.1288]

Several delivery systems with sigmoidal or pulsatile release patterns were derived on this ion exchange. The sigmoidal release system (SRS) consisted of pellet cores, containing drug and succinic acid, coated with Eudragit The lag time was controlled by the... [Pg.1290]

See other pages where Time-controlled pulsatile delivery is mentioned: [Pg.1287]    [Pg.1287]    [Pg.166]    [Pg.31]    [Pg.35]    [Pg.417]    [Pg.420]    [Pg.73]    [Pg.74]    [Pg.9]    [Pg.442]    [Pg.1012]    [Pg.314]    [Pg.45]    [Pg.420]    [Pg.11]    [Pg.3924]    [Pg.165]    [Pg.553]    [Pg.1095]    [Pg.172]    [Pg.350]    [Pg.189]    [Pg.290]    [Pg.179]   
See also in sourсe #XX -- [ Pg.1287 ]



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Controlled delivery

Delivery time

Pulsatility

Time control

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