Tiered toxicological safety approach

Tiered ToxicologicaUSafety Approach Botanical substances may be used at variable levels in personal care products. This together with the type of product to which the extract is being added will define the level of exposure to the consumer. The safety assessment approach can be flexible based on the level of botanical or natural substances in the product. The approach to these extracts is based on tiers. The first tier would be based on very conservative assumptions using worst-case scenarios and the last tier would require an in-depth knowledge of the exact composition if the botanical extract to be used and specific toxicological data to address all relevant endpoints. The three tiers addresses Type I dermal and systemic endpoints. Explanation as to how these tiers were set is provided in detail in the corresponding book chapter. 

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