Thyroid status determination, plasma

Knowledge of thyroid hormone binding in plasma, either by measuring the free hormone concentration or by determining TBG levels, may sometimes be needed in the as.sessment of a patient s thyroid status. 

Mancini A, De Marinis L, Calabro F, Sciuto R, Oradei A, Lippa S, Sandric S, Littarm GP, Barbarino A. Evaluation of metabolic status in amiodarone-induced thyroid disorders plasma coenzyme QIO determination. J Endocrinol Invest 1989 12(8) 511-16. 

The validity of the duplicate portion technique may be problematic as the completeness of duplicate portions is often difficult to assess. However, the use of biochemical markers, such as plasma, serum and urine, may be incorporated into nutritional assessment studies to validate dietary surveys or confirm nutritional status. There are a number of different methods that can be used to assess iodine status and, in particular, for the determination of the severity of iodine deficiency. However, two main methods used for the assessment of iodine status are measurement of urinary iodine excretion and thyroid function tests (an indirect method of iodine sufficiency). 

Iodine speciation has been successfully carried out using capillary electrophoresis coupled to inductively coupled plasma mass spectrometry. The status of iodine species (such as thyroxine, triiodothyronine or iodide) in serum or urine can give information about the malfunction of the thyroid gland and can explain other metabolic abnormalities. Chromium speciation is not normally required in biological samples because the body converts all of the Cr + to Cr + and so the measurement of total chromium in blood and urine is referred to when in fact Cr + has been determined. Chromium speciation has been carried out in bacteria culture medium, which has used to convert Cr + to Cr ". ... 

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