Thymidine triphosphate, pyrophosphate

TPP thiamine pyrophosphate Trp tryptophan TTP thymidine triphosphate Tyr tyrosine U uracil... 

L D. The conversion of penciclovir to its active form requires initial monophosphorylation by viral thymidine kinases, then conversion to its active triphosphate form by cellular enzymes. Thus, the concentration of penciclovir triphosphate is particularly high in cells infected with its target viruses (e.g., HSV, VZV, HBV). Foscarnet is a pyrophosphate analogue that does not require activation. Oseltamivir is a neuraminidase inhibitor that is con-... 

Isopentenyl pyrophosphate Multinucleated cells Omeprazole Parathyroid hormone Scoparic acid A Scoparic acid B Scoparic acid C Scopadulin Scopadulcic acid A Scopadulcic acid B Scopadulciol Scopadiol Standard error Median survival Time Thymidine kinase Triphosphate... 

The 5-(a-D-glucopyranosyl pyrophosphates) of guanosine, thymidine, adenosine, and cytidine are formed in the same manner from the respective triphosphates. A number of other glycosyl phosphates have also been observed to undergo similar reactions (see Table I). 

The 3 -0-phosphonomethyl compound 203 has been prepared by alkylation of 0-3 of thymidine, and was converted into the triphosphate analogue 204 by reaction with tributylammonium pyrophosphate, previously activated by car-bonyldiimidazole. Initial reaction of 203 with carbonyldiimidazole led to the formation of a dimeric pyrophosphonate of 203. Similar chemistry was also carried out on a-thymidine, and the substrate properties of the products 203 and its a-anomer towards DNA polymerases were studied. ... 

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