Thromboxanes biological activity

K. R. and Roberts, L.J. (1990). Formation of unique biologically active prostaglandins in vivo by a non-cyclooxygenase free radical catalyzed mechanism. Adv. Prostagland. Thromboxanes Leukotriene Res. 21, 125-128. 

M. Hamberg, J. Svensson, T. Wakabayashi, B. Samuelsson, Thromboxanes A new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. USA 72 (1975) 2994. 

The a,a-difluoro Reformatsky reagent has been applied extensively to the preparation of compounds containing the -CF2C(0)- group and its derivatives,2 since this functionality often confers enhanced biological activity. Typical examples include the preparation of selectively fluorinated thromboxane A2 analogues24 and the preparation of a difluoro-y-lactone intermediate which was subsequently converted to l-(2-deoxy-2,2-difluororibofuranosyl) pyrimidine nucleosides (Equation 4.10).25... 

The eicosanoids are a group of biologically active compounds containing 20 carbon atoms derived from arachidonic acid. The prostaglandins (Section 19.6) and the leukotrienes (Section 9.16) are two types of eicosanoids. Two others are the thromboxanes and prostacyclins. 

Each eicosanoid is associated with specific types of biological activity (Table 29.4). In some cases, the effects oppose one another. For example, thromboxanes are vasoconstrictors that trigger blood platelet aggregation, whereas prostacyclins are vasodilators that inhibit platelet aggregation. The levels of these two eicosanoids must be in the right balance for cells to function properly. 

Liston TE, Oates JA, Roberts LJ Jr. Prostaglandin D2 is metabolized in humans to 9-alpha, 11-beta-prostaglandin F2, a novel biologically active prostaglandin. Adv. Prostaglandin Thromboxane Leukot. Res. 

Dietary fat serves several important nutritional functions. It is the source of essential fatty acids. Members of the n-6 and n-3 (also known as the co-6 and co-3) families of fatty acids are important constituents of cell membranes and serve as precursors of eicosanoids (biologically active compounds such as prostaglandins, thromboxanes, prostacyclins, and leukotrienes). Fat also serves as a carrier for the fat-soluble vitamins, and it is important source of energy. In addition, it has important culinary properties and contributes to the palatability of food. 

Aimstrong RA, Jones RL, Wilson NH. Ligand binding to thromboxane receptors on human platelets correlation with biological activity. Br J Phannacol 1983 79 953-64... 

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