Thrombospondin platelets

Agbanyo FR, Sixma JJ, DeGroot PG, Laiguino LR, Plow EF. Thrombospondin-platelet interacti( is role of div ent cations, wail shear rate, and membrane Glyooprotein J Clin Invest 1993 92 288-296. 

CD35 C3b receptor CD36 Known to be z macrophage thrombospondin receptor CD40 Present on B cells and follicular dendritic cells CD41 Known to be z platelet glycoprotein... 

Other platelet membrane glycoproteins that are involved in adhesion reactions are GPIV and GPVI, which play a role in platelet interactions with and activation by collagen (6, 7). GPIV also functions as a receptor for the platelet alpha granule protein thrombospondin (2, 7, 8). Table 1 summarizes the functions of platelet membrane receptors. 

Clezardin, R, Malaval, L., Morel, M. C., et al, Osteonectin is an alpha-granule component involved with thrombospondin in platelet aggregation. J. Bone Miner Res. 6, 1059-1070 (1991). 

Leung, L. L. (1984). Role of thrombospondin in platelet aggregation./. Clin. Invest. 74, 1764-1772. 

Nitric oxide Platelet factor 4 CD 40 ligand PDGF RANTES Thrombospondin JGF-P, others... 

PDI is a noncovalent homodimer with a molecular weight of 57 kDa for each subunit. The protein is generally involved in the formation, reduction and rearrangement of disulfide bridges and plays an important role in platelet function. PDI is localized at the extracellular side of the plasma membrane and is secreted after platelet activation (Chen etal, 1992). In platelets, PDI catalyzes the formation of disulfide-bridged complexes of thrombospondin 1 and thrombin-antithrombin III and is thus involved in hemostasis and wound healing (Milev and Essex, 1999). 

Rybak ME. Glycoproteins Ilb and Ilia and platelet thrombospondin in a liposome model of platelet aggregation. Thromb Haemost 1986 55 240-245. 

Houdijk WP, de Groot PG, Nievelstein PF, Sakariassen KS, Sixma U Subendothelial proteins and platelet adhesion, von Willdvand factor and fibronectin, not thrombospondin, are involv in platelet adhesion to extracellular matrix of human vascular endothelial cells. Arteriosclerosis 6 24-33,1986. 

Lahav J Thrombospondin inhibits adhesion of platelets to glass and protem-covered substrata. Blood 71 1096-1099,1988. 

Hayward CPM, Rivard GE, Kane WH et al. An autosomal dominaitt, qualitative platdet disorder associated with muldmerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibriiK>gen, and an epinephrine aggr atirm defect Blood 1996 87 4967-4978. 

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