THRESHOLDS FOR GENOTOXIC CARCINOGENS EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES

THRESHOLDS FOR GENOTOXIC CARCINOGENS EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES 

Shoji Fukushima Min Wei Anna Kakehashi Hideki Wanibuchi 

Cancer Risk Assessment, edited by Ching-Hung Hsu and Todd Stedeford Copyright 2010 John Wiley Sons, Inc. 

LOW-DOSE CARCINOGENICITY OF 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-f]QUINOXALINE (MeIQx) IN THE RAT LIVER 

MeIQx is a heterocyclic amine contained in fried meat and fish. MeIQx at doses of I00-400ppm in the diet is carcinogenic in the rat liver (Kato et al. 1988). To investigate the effect of exposure to low doses of MeIQx, 1145 21-day-old male F344 

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