Three-dimensional structures rhinovirus

Badger, J., et al. Three-dimensional structures of drug-resistant mutants of human rhinovirus 14. /. Mol. Biol. 

In 1985 Dr. Michael Rossmann and his colleagues determined for the first time the three-dimensional structure of a human rhinovirus [15], Their studies, performed with human rhinovirus type 14 (HRV-14), revealed the structure as an eicosahedron consisting of four proteins designated VP1, VP2, VP3, and VP4 forming a protomeric unit, combined to form a fivefold axis of symmetry (Fig. 2). The surface of the capsid... 

Hewat, E. A., Marlovits, T. C., and Blaas, D. (1998). Structure of a neutralizing antibody bound monovalendy to human rhinovirus 2. J. Virol. 72, 4396-4402. Tormo, J., Stadler, E., Skem, H., Auer, H., Kanzler, O., Betzel, C., Blaas, D., and Fita, I. (1992). Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2. Protein Sci. 1, 1154—1161. 

This volume has been written for those chemists and biochemists who may never themselves do X-ray diffraction analyses of crystals, but who need to be able to understand the results of such studies on structures of immediate interest to them. The fields of structural biology and chemistry have blossomed in the years since X-ray diffraction was discovered in 1912. For example, the three-dimensional structures of benzene, graphite, the alkali halides, the boron hydrides, the rare gas halides, penicillin, vitamin Bjj, hemoglobin, lysozyme, transfer RNA, and the common-cold rhinovirus have been determined and, in each case, the results have greatly increased our understanding of fundamental chemistry and biochemistry. 

Ekins, S., G. L. Durst, R. E. Stratford, D. A. Thorner, R. Lewis, R. J. Loncharich, and J. H. Wikel. Three-dimensional quantitative structure-permeability relationship analysis for a series of inhibitors of rhinovirus replication, J. Chem. Inf. Comput. Sci. 2001, 41, 1578-1586... 

Wikel, /. Chem. Inf. Comput. Sci., 41, 1578 (2001). Three Dimensional Quantitative Structure Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication. 

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