Rossmann, Michael

In 1985 Dr. Michael Rossmann and his colleagues determined for the first time the three-dimensional structure of a human rhinovirus [15], Their studies, performed with human rhinovirus type 14 (HRV-14), revealed the structure as an eicosahedron consisting of four proteins designated VP1, VP2, VP3, and VP4 forming a protomeric unit, combined to form a fivefold axis of symmetry (Fig. 2). The surface of the capsid... 

Part of this receptor binds into a groove or "canyon," which in marked in (A) by the dark bands. From Olson et al.78 Courtesy of Michael Rossmann. 

Figure 7-28 (A) Stereoscopic view of the (])X174 114 S mature virion viewed down a twofold axis after a cryoelec-tron microscopy reconstruction. From McKenna et al.225 (B) Morphogenesis of < )X174 (based on a report of Hayashi etal.231). Proteins A and C are required for DNA synthesis. Drawing from McKenna et al.225 Courtesy of Michael G. Rossmann.

Figure 4.25 Diagram showing expected positions of reflections in an oscillation photograph. Diagram courtesy of Professor Michael Rossmann.

M.S.C. was supported by the American Cancer Society (RPG-99-365-01-GMC) and National Institutes of Health (R01-GM66875), and L.L. was supported by the Swedish Natural Science Research Council. M.S.C. wishes to thank Michael Rossmann, his postdoctoral mentor, for introducing him to virus structme, and several colleagues in the years since whose discussions have maintained this interest Jack Johnson, Lee Makowski, and Don Caspar. 

Michael Rossmann and Ada Yonat. Rossmann did important work on virus structures and made major contributions in crystallography over a long period of time. Ada Yonat for ribosome and for her work over a period of many years, her perseverance. It reminds me somewhat of my own experience. 

It is now better known as Molecular Replacement Method. Michael Rossmann and David Blow working in Cambridge, England rediscovered the method... 

Michael G, Rossmann, Anders Liljas, Carl-Ivar Brdnden, and Leonard J. Banaszak... 

J. John Holbrook, Anders Liljas, Steven J. Steindel, and Michael O. Rossmann... 

Most dehydrogenases that use NAD or NADP bind the cofactor in a conserved protein domain called the Rossmann fold (named for Michael Rossmann, who deduced the structure of lactate dehydrogenase and first described this structural motil). The Rossmann fold typically consists of a six-stranded parallel /3 sheet and four associated a helices (Fig. 13-16). 

J. JOHN HOLBROOK ANDERS LILJAS STEVEN J. STEINDEL MICHAEL G. ROSSMANN... 

MICHAEL G. ROSSMANN (61, 191), Department of Biological Sciences, Purdue University, West Lafayette, Indiana... 

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