Three-dimensional activity relationship

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In this section, the structure, function, and reactivity of amino acids, peptides, and proteins will be discussed with the goal of providing a foundation for successful derivatization. The interplay of amino acid functionality and the three-dimensional folding of polypeptide chains will be seen as forming the basis for protein activity. Understanding how the attachment of foreign molecules can affect this tenuous relationship, and thus alter protein function, ultimately will create a rational approach to protein chemistry and modification. 

Although structurally-diverse as evidenced above, the insecticidal pyrethroids still conform to a unique, operationally-defined, structure-activity relationship based on the physical characteristics and three-dimensional shape of the entire molecule conforming to those originally evidenced in the natural pyrethrins [13]. From this relationship, it becomes apparent that there is no single molecular aspect or reactive moiety that serves as a true toxophore for the pyrethroids and that their actions at target sites are dependent upon the entire stereospecific structure of these insecticides [1]. 

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