Third generation biomaterials

For even more biological related nanostructural bioceramics, stem cell produced materials are expected. However, a restriction is the time before cells in the biomaterial can be used. That s why combination of nanostructural CBBCs and stem ceU activity is likely in the development of these third generation biomaterials, especially if load-bearing properties are required. 

A common route that can be applied for obtaining polyhydroxyalkanoates with desirable functionalities is to produce PHAs with terminal double bonds followed by chemical modification steps. Carbon double bonds are comparatively inert but can be easily transformed into reactive functional groups under mild reaction conditions. Non-functionalized PHAs can also be activated by surface modification techniques. The resulting tailor-made structural and material properties have positioned polyhydroxyalkanoates well to contribute to the manufacturing of second and third generation biomaterials. ... 

The aim of the second project, 3G-SCAFF (Third Generation Scaffolds for Tissue Engineering Regenerative Medicine) , is to develop an extra-cellular matrix to be used as biomaterial. This matrix is a complex composition of essential materials oe cells live and grow. The cells are used as a micro foctory for the productirm and composition of a molecular structure - the extra cellular matrix - that cannot be produced with synthetic instruments. 

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