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Thiolated chitosan, mucoadhesive potentials

Poly(acrylic acid)-cysteine and chitosan-4-thiobulylamidine were evaluated as anionic and cationic polymers for the preparation of a DDS for riboflavin-S -monophosphate sodium salt dihydrate as a model drug. The particles had a mean diameter of 336.5 16.5 and 396.3 17.0 nm and a zeta potential of - 20.0 1.0 and -I- 27.2 0.5 mV, respectively. It was found that glutathione in combination with thiomers has a significant influence for increasing permeation, and that thiolated particles of both anionic and cationic polymers had improved mucoadhesive and controlled release properties. Therefore, they can be potentially applied as gastroretentive delivery systems. ... [Pg.300]

See other pages where Thiolated chitosan, mucoadhesive potentials is mentioned: [Pg.64]    [Pg.157]    [Pg.572]    [Pg.45]    [Pg.105]    [Pg.89]    [Pg.330]    [Pg.46]   
See also in sourсe #XX -- [ Pg.64 ]



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Chitosan thiolated

Chitosans mucoadhesion

Chitosans thiolated

Mucoadhesion

Mucoadhesive

Mucoadhesive potential

Mucoadhesiveness

Mucoadhesives

Mucoadhesives chitosan

Thiolate

Thiolates

Thiolation

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