Thiolactones, review

Thiolactones (including (3-thiolactones) have been reviewed. They are more easily formed and less easily ring-opened than their oxygen analogs, the /3-lactones. 

A review article, dealing with the synthesis of heterocycles starting from lactones, lactams, and thiolactones, has appeared. ... 

Hey concentration and decreases with increasing folic acid and HDL in EC cultures. All this suggests a role in vascular disease (149). Hey thiolactone combines with native LDL to form oxLDL, which is taken up by intimal macrophages to form foam cells (reviewed in ref. 150). 

The chemistry of propiothiolactone derivatives has been extensively studied since 1955, when Knunyants and coworkers prepared first substituted 3-thiolactones [1]. Several efficient methods for the preparation of propiothiolactones have appeared since in the literature, but in contrast to j3-lactones , it is surprising how little work concerning the polymerization of / -thiolactpnes was published in the current chemical literature. In a review of the work published up to 1964 only one example of the preparation of poly-pro-piothiolactone is mentioned [2]. It refers to the preparation of (/ )(-)-poly-(a-phthalimido-j3-thiolactone) by debenzylation of a-phthalimido- 3-benzylmercaptopropionyl chloride under the conditions of Friedel-Crafts synthesis [3]. 

The major part of this article reviews the preparation of poly- 3-thiolactones, especially optically active polymers, while in the first part a brief survey of the monomer synthesis is included. 

The current interest in thiolactone chemistry in synthetic polymer science, disseminated in at least 15 original peer-reviewed papers since 2011, is an indication that it entails more than the solving of some thiol-related problems. It has indeed been recogiuzed that this concept holds two particular advantages compared... 

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