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Thiazoles, 2-acyl formylation

Although in general azoles do not undergo Friedel-Crafts type alkylation or acylation, several isolated reactions of this general type are known. 3-Phenylsydnone (120) undergoes Friedel-Crafts acetylation and Vilsmeier formylation at the 4-position, and the 5-alkylation of thiazoles by carbonium ions is known. [Pg.58]

On the other hand, several nucleophilic reagents and catalysts have been found capable of promoting the ring expansion of 4-formyl p-lactams, and/or their imine derivatives, to afford open chain acyl thiazole or succinimide derivatives. For example, treatment of 4-formyl p-lactam 199 with 2-(trimethylsilyl)thiazole,... [Pg.247]

Thiazoles, 2-acyl-, 13 formylation of, 73 halogeno-, 296, 347, 348 nucleophilic substitution of, 370... [Pg.217]

See other pages where Thiazoles, 2-acyl formylation is mentioned: [Pg.295]    [Pg.175]    [Pg.137]    [Pg.68]    [Pg.392]    [Pg.51]    [Pg.506]    [Pg.383]   
See also in sourсe #XX -- [ Pg.73 ]



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Acylation/formylation

Thiazole 2- -, acylation

Thiazoles, 2-acyl

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