Thiazole 2-methylthio-5-phenyl

Thiazole, 4-methyl-5-(2-hydroxyethyl)-in thiamine biosynthesis, 1, 97 Thiazole, 4-methyl-2-methylami nosynthesis, 6, 300 Thiazole, 4-methyl-2-phenyl-alkylation, 6, 256 mercuration, 6, 256 Thiazole, 2-(methylthio)-methylation, 6, 290 thermodynamic values, 6, 291 Thiazole, 2-methylthio-5-phenyl-synthesis, 5, 153 Thiazole, 4-methyl-5-vinyl-occurrence, 6, 327 Thiazole, 2-phenyl-acetylation, 6, 270-271 Conformation, 6, 237 synthesis, 5, 113, 6, 306 Thiazole, 4-phenyl-conformation, 6, 237 2,5-disubstituted synthesis, 6, 304 Thiazole, 5-phenyl-conformation, 6, 237 Thiazole, 2-phenyl-5-triphenylmethyl-synthesis, 6, 265 Thiazole, 2-(2-pyridyl)-metal complexes, 5, 51 6, 253 Thiazole, 4-(2-pyridyl)-metal complexes, S, 51 6, 253 Thiazole, tetrahydro-ring cleavage, 5, 80 Thiazole, 2,4,5-trimethyl-occurrence, 6, 327... 

Thiazoline, 2-methylthio [Thiazole, 4,5-dihydro-2-(methylthio)-], 82 2-Thiazolme, 2-(4-phenyl 1 buten-3-yl)thio-[Thiazole, 4,5-dihydro-2-[ [ l-(phenyl-methyl)-2-propenyl] thio] -], 78 Tluazolium,. V-inethyl-2-methylthio-,... 

Alkylation of 5-phenylrhodanines (122) with alkyl iodides and sodium ethoxide yields the meso-ionic 2-alkylthio-l,3-thiazol-4-ones (114, R = SR) 78a structure of the compound 114, R = SMe, R = NHj, R = Ph, was established by X-ray analysis. The dipole moment of the compound 114, R = R = Me, R = Ph, in benzene solution is 5.21 D. Irradiation of the meso-ionic l,3-thiazole-4-thione (114, R = SMe, R = Me, R = Ph) in ethanol yields the isomeric 3-methyl-4-methylthio-5-phenyl-l,3-thiazol-2-one. A novel mechanism for this photochemical rearrangement has been proposed. ... 

Isothiocyanat 4-Aminosulfonyl-phenyl- E4, 838 (NH2 > NCS) Pvrido[2.3-d]-13-thiazol 5,7-Dihydroxy-2-methylthio- E8b,... 

Dithiazolium 3-Methylthio-5-phenyl- -perchlorat E8d, 35 [5-Ar - 3-thiono - 3H-1,2,4-di-thiazol -f (H3CO)2S02]... 

Bei der Reaklion von (Methoxy-thioearbonylthio)-essigsaure-methylester mit Phenyl-isothiocyanat und ansehlieBender Methylierung entsteht neben 5-Methoxycarbonyl-4-methylthio-3-phenyl-2-thiono-2,3-dihy-clro-1,3-thiazol in Spuren 2-Methylthio-S-(methylthio-carbonyl)-3-phenyl-l, 3-thiazolium-4-olat (6% Schmp. 244 )1B5°. 

Amino-2-methylthio-5-(4-nitro-phenyl)-1,3-thiazol (R = 4-N02C6H4 X = SCH3)RRI Eine Losung von 26,7 g (0,1 mol) Dithiokohlensaure-cyanimid-S-methylestcr-S-(4-nitro-benzylester) in 50 ml Aceton wird mit 5 ml Triethylamin versetzt und 2 h untcr RuckfluC erhitzt. AnschlieBend wird das Losungsmittel i. Vak. abdestillicrt und der Riickstand aus Ethanol umkristallisiert Ausbeute 18,7 g (70%) Schmp. 173°. 

Bei der Einwirkung von Trimethyloxonium-tetrafluoroboratauf 5-Phenyl-2-(2-phenyl-ethenyl)-3-thiono-2,3-dihydro-1,2-thiazol wird unter S-Methylierung und IJmlagerung ein 1,3-Thiazol erhalten, das die Methylthio-Gruppe in der Seitenkette tragt897 ... 

Die S,N-Bindung von 3-Cyan-2-methyl-6-phcnyl-[Pg.233]

Thiazole konnen durch Reaktionen an den Substituenten ihren aromatischen Charakter verlieren. So tritt beispielsweise am 3-Methyl-2-methylthio-5-phenyl-l,3-thiazolium-perchlorat beim Erhitzen in Pyridin eine Abspaltung der S-standigen Methyl-Gruppe auf567. Dadurch entsteht 3-Methyl-5-phenyl-2-thiono-2,3-dihydro-1,3-thiazol (95%)567 ... 

Cyan-2-(N-methyl-anilino)-4-methyl- 68 2-(Cyan-methyl)-4-hydroxy- 8, 10, 11 5-Cyan-2-methyl-4-phenyl- 152 5-Cyan-2-(4-methyl-phenyl)-4-trinuormethyl-a us 5-F1 uor-2-(4-methyl-phenyl)-4-trifl uor-methyl-1,3-thiazol/Kaliumcyanid 297 2-[l-Cyan-l-(methylthio-thiocarbouyl)-methyliden -4-pheny l-2,3-dihvdro- 233 5-Cyan-2-morpholino-4-phenyl- 136 2-[2-(3-Cyan-phenyl)-ethenyl]-4-isopropyl- 312... 

A soln. of dimethyl N-(ethoxycarbonylmethyl)iminodithiocarbonate in THF added drop wise to a stirred soln. of K-/cr/-butoxide in the same solvent at -78° under N2, a soln. of phenyl isothiocyanate in the same solvent added slowly after 30 min, stirring continued at —78° for an additional 30 min, the mixture allowed to stand at room temp, for 2 h, then quenched with water 4-ethoxycarbonyl-2-methylthio-5-anilino-thiazole. Y 90%. F.e.s. C. Alvarez-Ibarra et al.. Heterocycles 27, 2177-83 (1988). 

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