Thermosensitive CBNs

Chitosan-g-NIPAM-co-N, N-dimethylacrylamide nano carrier encapsulating magnetite core (Fe O ) coupled with a drug via an acid-labile hydrazone bond It showed thermoresponsive behavior with a LCST of 38°C and faster drug release at pH 5.3. [32] 

5-fluorouracil-loaded thermosensitive chitosan-g-PVCL nanoparticles Nanoparticles showed higher toxicity to cancer cells with LCST at 38°C, while being less toxic to normal cells. [33] 

Carboxyl-terminated NIPAA/vinyl laurate (VL) copolymer with chitosan (CNVLC) Enhanced transfection with thermoresponsive CNVLC/DNA complexes in C2C12 cells. [34] 

Biodegradable chitosan hydrogel using N-acryloylglycine and IPN chitosan hydrogel using PEG diacrylate Both of them showed potential utility for controUed-relecise applications. [41] 

Chitosan-PA A hollow nanospheres prepared using core-template-free strategy Flexibility to manipulate size by changing the pH, salt concentration, and temperature. They can also be suitable candidates for controlled drug release and gene dehvery. [42] 

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Table 4.3 Potential applications of pH-sensitive and thermosensitive CBNs.

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