Thermoresponsive gelatin

Takamizawa, K., Shoda, K., Matsuda, T. (2002). Pull-out mechanical measurement of tissue-substrate adhesive strength endothelial cell monolayer sheet formed on a thermoresponsive gelatin layer. Jourrud of Biomaterials Scierwe Polymer Edition, 13, 81-94. 

Ohya, S., Matsuda, T., Poly(N -Isopropylacrylamide) (PNIPAM)-Grafted Gelatin as Thermoresponsive Three-Dimensional Artificial Extracellular Matrix Molecular and Formulation Parameters vs. Cell Proliferation Potential, Riomater. Sd. Polvm. Fdn. 2005, 16, 809-827. 

In general, naturally occurring polymers do not exhibit thermal responsiveness. Various strategies were envisioned to confer this physicochemical property to polysaccharides, such as chemical modification or formation of interpenetrated networks with other thermoresponsive polymers. Most of the published works report the use of thermoresponsive hydrogels based on PNlPAAm (Rzaev et a/., 2007). Examples of copolymers which may be grafted with PN IPAAm are chitosan (Martins e/ /., 2011), de xtran (Huang and Lowe, 2005 Huh et al, 2000), gelatin (Ohya and Matsuda, 2005), or... 

Ohya, S. and Matsuda, T. (2005). Poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin as thermoresponsive three-dimensional artificial extracellular matrix molecular and formulation parameters vs. cell proliferation potential. Journal of Biomaterials Science-Polymer Edition, 16,809-827. 

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