Thermoresponsive biodegradable polymer

The inclusion of the thermoresponsive poly(Af-isopropylacrylamide) (PNIPAM) constituent suggests the advantages of (1) degradation mechanism modulation of biodegradable polymers, (2) cytotoxicity reduction of polycationic polymers, (3) thermally localizing medication to target sites after systemic administrations while their lower critical solution temperature (LCST) is tailored to temperatures between 37°C (body temperature) and 42°C (used habitually in clinical hyperthermia), and (4) drugs released at diverse profiles in answer to stimuli such as temperature, pH, etc. [69]. 

WA3 Wang, Y.-C., Xia, H., Yang, X.-Z., and Wang, J., Synthesis and thermoresponsive behaviors of biodegradable Pluronic analogs, J. Polym. Sci. Part A Polym. Chem., 47, 6168, 2009. 

Yoshida, T. et al, 2003. Newly designed hydrogel with both sensitive thermoresponse and biodegradability. Journal of Polymer Science Part A Polymer Chemistry, 41, 779-787. 

Rudolph, C., and Agarwal, S. (2007) Biocompatible, thermoresponsive, and biodegradable simple preparation of all-in-one" biorelevant polymers. Macromolecules, 40, 8540. 

The literature on controlled release from amphiphilic polymer aggregates is reviewed. Two terms, biodegradation and organisation of polymers, are discussed as characteristic points for the authors approach to polymer aggregates. Microcapsules are considered, with particular reference to sustained release from polypeptide microcapsules, pH-responsive release from polypeptide microcapsules, thermoresponsive microcapsules, and degradation. Microspheres are then discussed and polypeptide vesicles are examined. 81 refs. JAPAN... 

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