Diversity profiling

Agrafiotis D K, J C Myslik and F R Salemme 1999. Advcinces in Diversity Profiling and Combinatorial Series Design. Molecular Diversity 4 1-22. 

Pickett S D, J S Mason and IM McLay 1996. Diversity Profiling and Design Using 3D Pharmacophore Pharmacophore-Derived Queries (PDQ). Journal of Chemical Information and Computer Scien 36 1214-1223. 

S Pickett, IS Mason, IM McLay. Diversity profiling and design using 3D pharmacophores Pharmacophore-derived queries (PDQ). I Chem Inf Comput Sci 36 1214-1223, 1996. 

Agrafiotis DK, Myslik JC, Salemme FR. Advances in diversity profiling and combinatorial series design. Mol Div 1999 4 1-22. 

Pickett, S.D., Mason, J.S., and Mclay, l.M. Diversity profiling and design using 3D pharmacophores ... 

Blackwell, L., Norris, J., Suto, C.M. and Janzen, W.P. (2008) The use of diversity profiling to characterize chemical modulators of the histone deacetylases. Life Sciences, 82, 1050-1058. 

Agrafiotis, D. K., Myslik, J. C., and Salemme, F. R. (1999) Advances in diversity profiling and combinatorial series design. Annu. Rep. Comp. Chem. Mol. Diversity 2, 71-92. 

Gray LE, Wolf C, Lambright C, et al. 1999. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinatc,/ ./ -DDE, and ketoconazole) and toxic substances (dibutyl-and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformation in the male rat. Toxicol Ind Health 15 94-118. 

Start by gaining a realistic and up-to-date understanding of the organization s diversity profile at all levels (workforce representation). 

As the same pressure head - possibly with exchangeable inserts - is frequently used for the extrusion of diverse profiles, particular priority must be given to fast changing of the dies. The tool can be fixed either by screws, or with the aid of a bayonet catch, or by means of hydraulically-actuated locks. 

In order to create such organizations, there is a need to introduce new and transformed mechanisms of voice that use systems and structures relevant to both new forms of work and increasingly diverse profiles of current and potential workers. " ... 

A number of studies have used an alternative approach to assess descriptor quality for diversity profiling. In these studies, descriptors were ranked by their ability to discriminate active and inactive compounds within a number of medicinal chemistry project data sets. In the work of Brown and Martin, this discrimination involved the ability to separate one class of compounds from a general pool of compounds. The approach put forward by Patterson et al. i (see also Refs. 132 and 133) introduced the concept of neighborhood behavior that is, compounds close in biological space should have a small difference in descriptor values. In these studies, it was suggested that 2-D fingerprints and simple shape descriptors make better descriptors than other alternatives... 

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