Thermo lytic

Saito et al. achieved the first direct confirmation of double alkylation of purine bases by azinomycin B [140]. They incubated azinomycin B with the self-comple-mentary DNA duplex d(TAGCTA)2 and monitored the reaction by HPLC and ion spray MS. They observed initial formation of a monoadduct that was then converted into a crosslinked bisadduct. The crosslink position was identified as between the guanine of one strand and the 5 -adenine on the other strand by thermo-lytic depurination. Further decomposition prevented structural analysis of the azi-... 

Alvarez-Toledano has investigated149 the reactivity of tertiary amines toward vinylketene complexes of type 221 and found that a number of unusual transformations take place. The formation of 237 and 238 is not directly linked to the presence of the amine, but instead relies on a thermo-lytic coupling of two carbene complexes formed from the vinylketene ligand, with additional loss of carbon monoxide. It is thought that 239 is formed by the deprotonation of the labile C-4 proton, followed by subsequent coordination of a capping Fe(CO)3 group. 

The chiral dipolarophiles of Garners and Dogan, which were derived from Oppolzer s sultam, have been previously discussed in Section 3.2.1 and, in an extension to these results, the sultam moiety was used as the stereodirecting unit in enantiopure azomethine ylides (56). The ylides were generated either by thermo-lytic opening of N-substituted aziridines or by the condensation of the amine functionality with benzaldehyde followed by tautomerism. These precursors were derived from the known (+)-A-propenoylbornane-2,10-sultam. Subsequent trapping of the ylides with A-phenylmaleimide furnished the cycloaddition products shown in Schemes 3.60 and 3.61. 

The impure material is very explosive [1]. The pure material, prepared by a thermo-lytic method, is stable as a solid at —103°C, but on melting it decomposes to ammonium hydrogen difluoride and nitrogen [2],... 

Dougherty, R. C. The Relationship between Mass Spectrometric, Thermo lytic and Photolytic Reactivity. 45, 93—138 (1974) Dryhurst, G. Electrochemical Oxidation of Biologically-Important Purines at the Pyrolytic Graphite Electrode. Relationship to the Biological Oxidation of Purines. 34, 47-85 (1972)... 

Pt(ll) complexes with bidentate N-donor (2,2 -bipyrydyl, 2,2 -bipyrimidyl, 1,10-phenanthroline and substituted 1,10-phenanthrolines) and P-donor (tri-methylphosphine, triphenylphosphine) ligands undergo quantitative thermo-lytic metallacyclization with the elimination of icri-butylbenzene to yield stable platinacycles [Eq. (6.65)] ... 

Numerous manufacturers of analytical instruments and other products and services related to analytical chemistry have contributed by providing diagrams, application notes, and photos of their products. We are particularly grateful to Agilent Technologies, Bioana-lytical Systems, Beckman Coulter. Inc.. Brinkman Instruments, Caliper Life Sciences, Hach Co., Hamamatsu Photonics, InPhotonics, Inc, Kaiser Optical Systems, Leeman Labs, LifeScan, Inc., Mettler-Toledo, Inc., National Instruments Corp.. Ocean Optics, Inc., Perkin-Elmer Corp., Postnova Analytics, Spectro Analytical Instruments, T. A. Instruments, Thermo-Electron Corp., and Varian, Inc. lor providing photos. 

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