Therapeutic drug management pharmacokinetics

Therapeutic drug management (TDM) of most antidepressants is not widely available or widely utilized, for any clinical indication. The primary benefits of TDM in the management of antidepressant therapy could include assessment of patient compliance, detection of drug-drug interactions or altered pharmacokinetics, and evaluating the concentration relationship of individual patient response and/or thresholds for dose-related side effects. Of all the classes of antidepressant drugs, TDM of TCAs is most common. 

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Coukell, AJ. and Faulds, D. 1997. Epirubicin An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of breast cancer. Drugs. 53 453. 

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Pharmacokinetics describes the processes of the uptake of drugs by the body, the biotransformations they undergo, the distribution of the drugs and their metabolites in tissue, and the elimination of the drugs and their metabolites from the body. Clinical pharmacokinetics is the discipline that applies the principles of pharmacokinetics to safe and effective therapeutic management of an individual patient. It is this aspect of pharmacology that most strongly influences the interpretation of TDM results and that is dealt with in more detail in this chapter. 

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Perry CM, Faulds D. Lamivudine. A review of its antiviral aotivity, pharmacokinetic properties, and therapeutic efficacy in the management of FIIV infeotion. Drugs 1997 53 657-680. 

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