Therapeutic, analytical chemistry

In this section, we present theoretical calculations on BPHTs related to their antitumour therapeutic properties and various applications concerning photoresist technology and analytical chemistry. 

Knowledge of the principles of kinetics (rate processes), analytical chemistry and therapeutics is essential in providing an effective concentration of a drug at the "site of action."... 

Beck, A., Wagner-Rousset, E., Ayoub, D., et al. (2012) Characterization of Therapeutic Antibodies and Related Products. Analytical Chemistry, 85 (2), 715-736. 

Xu, Y., Mehl, IT, Bakhtiar, R., et al. (2010) Immunoaffi-nity purification using anti-PEG antibody followed by two-dimensional liquid chromatography/tandem mass spectrometry tor the quantification of a PEGylated therapeutic peptide in human plasma. Analytical Chemistry, 82, 6877-6886. 

Thevis, M., Ogorzalek-Loo, R.R., Loo, J.A., and W. Schanzer. (2003) Doping control analysis of bovine hemoglobin-based oxygen therapeutics in human plasma by LC-electrospray ionization-MS/MS. Analytical Chemistry, 75,3287-3293. 

Wu, S.L., Jiang, H., Lu, Q., et al. (2009) Mass spectrometric determination of disulfide linkages in recombinant therapeutic proteins using online LC-MS with electron-transfer dissociation. Analytical Chemistry, 81, 112-122. 

These adsorbants are based on immobilised ligands, which have a high affinity for a particular analyte (Fig. 15.13). There are examples where antibodies have been raised to an analyte and then bound to the surface of a SPE matrix. Various types of chemistry permit this type of immobilisation and affinity chromatography is well established in biochemistry. With the proliferation with biotechnological products such as therapeutic peptides, the use of these types of columns for extraction may increase since they can be designed to be highly selective for such compounds. 

In addition to being necessary for all forms of life, biopolymers, especially enzymes (proteins), have found commercial applications in various analytical techniques (see Automated instrumentation, clinical chemistry Automated instrumentation, hemtatology Biopolymers, analytical techniques Biosensors Immunoassay) in synthetic processes (see Enzyme applications, industrial Enzyme applications in organic synthesis) and in prescribed therapies (see Enzyme applications, THERAPEUTICS IMMUNOTHERAPEUTIC AGENTS Vitamins). Other naturally occurring biopolymers having significant commercial importance are the cellulose (qv) derivatives, eg, cotton (qv) and wood (qv), which are complex polysaccharides. 

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