Therapeutic agents phenol

The enantiomerically pure diarylmethylpiperzine derivative, (-)-3-((S)-((2S,5R)-4-allyl-2,5-dimethyl-l-piperazinyl)-(3-thienyl)-methyl)phenol, (VI), prepared by Chang (5) was effective as an opioid receptor antagonist and used as a therapeutic agent in treating drug and alcohol addictions. 

Phenol is widely used as an antiseptic, disinfectant, and therapeutic agent, although it should not be used to preserve preparations that are to be freeze-dried. ... 

Although phenolic compounds and terpenoids are very effective in cells as well as in animal models, human studies have not yet explored the hidden potential of these compounds. Many of the studies using phenolic compounds and terpenoids have used higher concentrations than can be obtained physiologically from dietary intake, suggesting a role of functional foods in prevention and treatment of diseases. In this chapter, we review the status of phenolic compounds and terpenoids as potential therapeutic agents, with an emphasis on the role of oxidative stress and the presence of redox-active plant compounds in diets. 

Soobrattee, M.A., Neergheen, V.S., Luximon-Ramma, A., Aruoma, O.I., and Bahorun, T. 2005. Phenolics as potential antioxidant therapeutic agents mechanism and actions. Mutation research, 579(1-2), 200-13. 

Phenolic natural products (acylphloroglucinols) from the male fern Dryopteris filix-mas. The natural product is a mixture of six homologues (R, R =methyl, ethyl, propyl) with three main components, see table. Use F. exhibit anthelmintic activity. Ether extracts or solutions of the active principles in a fatty oil in combination with the subsequent administration of a laxative are used as a remedy for tapeworms. As a result of the low therapeutic range and the difficulties in standardization, F. have been mostly replaced by synthetic agents (they are still used occasionally in veterinary medicine). 

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