Therapeutic agents oximes

Hydroxylamines and oximes Biological properties and potential uses as therapeutic agents... 

The therapeutic action of oximes resides largely In their capacity to reactivate cholinesterases without contributing markedly toxic actions of their own at recommended or usual doses. Other actions may contribute to their effectiveness they may react directly with the anticholinesterase agent,4 4 block its reaction with cholinesterase, 0 modulate the release of acetylcholine, 30,74 block acetylcholine s agonistic activity... 

Red blood cell enzyme activity returns at the rate of red blood cell turnover, which is 1 % per day. Tissue and plasma activities return with synthesis of new enzymes. The rates of return of these enzymes are not identical. However, the nerve agent can be removed from the enzymes. This removal is called reactivation, which can be accomplished therapeutically by the use of oximes prior to aging. Aging is the biochemical... 

The therapeutic efficacy of oximes is usually focused on the evaluation of the protective ratio (PR), which is the ratio of the LD50 value of nerve agents for therapeutically protected animals to the LD50 value of nerve agents for unprotected animals. The authors usually publish data obtained from experiments where a combination of atropine and an oxime is used as an antidotal treatment because this possibility is much more relevant to anticipated military use than atropine or oxime alone. The results of published experiments are listed in Table 4(10, 32-47). 

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