Cimetidine tablets

Tablet hardness is a property that, when measured, destroys the sample. The destructive nature of the test, coupled with the variability of the test itself does not contribute to an incentive to test a large number of samples. Morisseau and Rhodes99 correlated the diffuse reflectance NIR spectra of tablets pressed at different pressures and subsequently tested the tablet hardness with an Erweka Hardness Tester. The tablet hardness, as predicted by the NIR method, was at least as precise as the laboratory test method. Kirsch and Drennen100 evaluated NIR as a method to determine potency and tablet hardness of Cimetidine tablets over a range of 1-20% potency and 107-kPa compaction pressure. Hardness at different potency levels was used to build calibration models using PCA/ principal component regression and a new spectral best-fit algorithm. Both methods provided acceptable predictions of tablet hardness.

Two formulations, for ampicillin and cimetidine tablets, that have been developed on a laboratory scale, are given in Table 173 as examples for the use of copovidone in the binder solution granulation. It is also highly suitable for producing preparations such as multivitamin granules [368 c]. 

Figure 1 Spectra of 20% cimetidine tablets with hardness varying from 1.5 kp (bottom) to 6.5 kp (top). Note the increasing baseline and increasing slope as hardness increases.

Choline Theophyllinate Tablets (100 mg) Chymotrypsine Tablets (27 mg) Cimetidine Tablets (200 mg) Cimetidine Tablets (280 mg) Cimetidine Tablets (400 mg) Clenbuterol Tablets (20 pg)... 

Tagamet (cimetidine) tablet and syrup (iimo-vator products administered orally via two different dosage forms)... 

Dou, Y., et al., Nondestructive quantitative analysis of cimetidine tablets using artificial neural networks in near-infrared spectroscopy. Spectrosc. Lett., 38 1-11 (2005). 

Konjac glucomannan (AmorphophaUus konjac K. Koch, Araceae family) and konjac glucomannan-xanthan (1 1) gum mixtures are used as excipients for controlled drug delivery of small molecules, for up to an eight hour period, due to the gel formation [260]. In addition, konjac glucomannan and xanthan gum are recommended as compression coatings for colonic drug delivery of cimetidine tablets [261]. 

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