Theophylline adverse drug reaction

A study in 17 patients with chronic obstructive pulmonary disease found that nizatidine 150 mg twice daily for a month had no effect on the steady-state pharmacokinetics of theophylline. However, there were 6 reports of apparent interactions in the Spontaneous Adverse Drug Reaction Database of the FDA in the US up to the end of August 1989. Four patients taking theophylline developed elevated serum theophylline levels, with symptoms of toxicity in at least one case, when given nizatidine. The problems resolved when either both drugs, or just nizatidine were stopped. ... 

Adverse reactions to drugs differ in both type and incidence in the pediatric population. Because of immature metabolic pathways, infants and children may have different metabolic patterns than adults. This at least partially explains why neonates require lower theophylline serum concentrations for the treatment of neonatal apnea and why the incidence of hepatotoxi-city following acetaminophen overdose is much lower in young children than in adults [44,45]. Antibiotic adverse effects unique to the pediatric population may... 

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