The use of factorial designs in physical tablet stability studies

2 The use of factorial designs in physical tablet stability studies 

Section 8.2 describes the feasibility of the use of the Storage to Initial Ratio as a measure to express the physical stability of tablets. By expressing the stability as the relative value after storage related to the initial value, it is 

In section 8.3 a study is described in which the SIR of crushing strength and the SIR of disintegration time are used to evaluate batches of tablets prepared for several combinations of filler-binders and disintegrants, with respect to their physical stability after storage under tropical conditions. 

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