The use of D.F.P. in post-operative paralytic ileus

The treatment consisted of intramuscular injection of 1 5 ml of 0 1 per cent solution of D.F.P. in sterile arachis oil, thus 

Some of the results obtained by these workers may be summarized as follows  

The writer would point out that the above conclusions were reached only with D.F.P., and it may well be that the physical properties of some other phosphorofluoridate might render it more suitable for this type of investigation. It may be noted, for example, that dicyclohexyl phosphorofluoridate, which is stable to hydrolysis (p. 52), has not yet been tried clinically. 

Protection in vitro of chcHinesteraaea against organo-phosphorus compounds 

Work has been carried out to discover compounds which would protect cholinesterases against inhibition by tabun, sarin and D.F.P. Sixteen amino acids were examined for this purpose in connexion with sarin and only D.O.P.A. (3 4-dihydr03gr 

One definition of post-operative paralytic ileus is the failure of the patient to pass faeces or fiatus within 60 hr. of the termination of a surgical abdominal operation . A somewhat similar condition may arise in cases of gross mechanical obstruction of the gut. It is well known also that operations involving handling of the gut or the peritoneum are especially liable to cause paralytic ileus. Peritonitis and post-operative pain, inadequately treated with morphia, also precipitate paralytic ileus. Pneumonia, meningitis and typhoid predispose to paralytic ileus, whilst severe hypothyroidism can also be complicated by a paralytic ileus. 

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