The Third-Generation Pill

It is noteworthy that Rudolf Wiechert (Fig. 6.18) at Scheringhad already synthesised drospirenone back in the 1970s. [72] However, it took around 25 years before the pharmacological potential of this compound was fiiUy recognised and the drug received market approval. From a chemical viewpoint, drospirenone is an attractive molecule. Unusual structural characteristics are the two cyclopropane rings and the spirolactone moiety. In contrast to the previous 

In the year 2000, Sobering introduced the contraceptive Yasmin , which contains 3 milligrams of drospirenone and 30 micrograms of ethynyloestradiol. In 2004 followed Angeliq , a combination product as hormone replacement for women during menopause, and for prevention of post-menopausal osteoporosis, with 0,5 milligrams of drospirenone and 1 milligram of oestradiol. 

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