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The Search for a Biodynamic Principle

For a proton flux to occur from the site of ATP hydrolysis to a distant [Pg.545]

Can the phenomenon of H -flux mediated electro-osmosis provide the biodynamic principle which we have been looking for It is clear that cellular transport processes such as axonal transport and cytoplasmic streaming could directly result from proto-osmosis if the ATPases inject protons into the filamentous systems. Ciliary movements could possibly result from a periodic proto-osmotic insurge of fluid in the cilia. A relative (contractile) movement of two sets of filaments could be caused by a proto-osmotic loop flow between the pairs of the filaments by means of the associated visous drag couple. But the question of the relevance of the effect can be solved only if it can be shown that the magnitude of the effect is sufficient, quantitatively, to explain at least one biodynamic phenomenon. The best-studied system in this context, from structural and biochemical aspects, is that of muscles. The necessary quantitative data for the comparision of theoretical result with experiments is available, but it has to be first confirmed that the conditions for the proposed electro-osmotic flow obtain in muscles. [Pg.547]

In the contractile apparatus of striated muscles it is relatively easy to identify and locate the source, the conductors, and the sink of protons. The ATPase is located in the cross-bridges creatine phosphokinase, CPK, the enzyme catalyzing the (proton-consuming) Lohmann reaction, in the struc- [Pg.547]


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