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The parameters most frequently used in human and mammalian PBTK models

Cardiac output Partition coefficients Rate constants (V, for [Pg.59]

Tissue blood flow Blood-water (fish) Biliary excretion [Pg.59]

Glomerular filtration rate Skin-air Macromolecular binding constants [Pg.59]

Tissue blood content Skin-water Bmax [Pg.59]

Tissue lipid and water content Skin surface area Permeability coefficients K, [Pg.59]


Table 2.1 The parameters most frequently used in human and mammalian PBTK models... Table 2.1 The parameters most frequently used in human and mammalian PBTK models...



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Frequent use

Mammalian models

Model parameter

Modeling, use

The parameters

Using the Model

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