The Neuroimmune System in Psychiatric Disorders

Keywords Alpha-melanocyte stimulating hormone Adre-nocorticohophic hormone Corticohopin releasing hormone Cytokines Depression Hypo thalamic-pituitary-adrenal axis Proenkephalin Proopiomelanocortin Schizophrenia Shess response 

Interactions between the immune and nervous system are complex and attempts to decipher these are still incomplete. One of the first empirical findings in support of an interaction between these systems was the discovery of receptors for neurohormones and neuropeptides on cells of the immune system (Hadden et al., 1970 Wybran et al., 1979 Hazum et al., 1979 Landmann et al., 1981). This implied that immune cells can and do respond to the endogenous Ligands for these receptors. Conversely, the demonstration of many cytokine receptors and the cytokines themselves in the CNS suggests not only that these small proteins have a functional role in the CNS, but that cytokines released by the immune system may be able 

Neurohormones and Their Receptors Associated with Both the Central Nervous System and die Immune System 

Most lymphoid tissues are innervated by the sympathetic nervous system, both directly and indirectly. These same tissues express receptors for a variety of hormones, including classical 

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