The Kinome and its Impact on Medicinal Chemistry

For the last few years protein kinases have been among the most actively studied pharmaceutical targets. In 2005 it was estimated that around one in three discovery efforts targeted protein kinases.3 Federov et al. surveyed the 

RSC Drug Discovery Series No. 19 Kinase Drug Discovery 

Edited by Richard A. Ward and Frederick Goldberg Royal Society of Chemistry 2012 

CMGC containing the Cyclin-dependent, Mitogen-activated, Glycogen synthase, and CDK-like kinases 

1RAK3 USkLKTAKI AUdBMPRIa IRAK3 LISI SB fC1g J[2 

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