The Design of Packed Columns for GC and LC

The Design Protocol must contain three different data sources which, for convenience, will be termed the Design Data Bases. The first data base will contain the exigencies of the analyst and will be given the title Performance Criteria. The performance criteria must contain explicit statements, given, wherever possible, in numerical terms that define the quality of the separation that is required in order to achieve an accurate analysis. 

The apparatus employed for any given analysis will have operating specifications that are unique to the particular instrument that is selected or that is available. These specifications have been determined by the design and method of manufacture of the instrument and can differ significantly from one chromatograph to another. Some will control and limit the ultimate performance achieved by any column with which the instrument is used. However, it is likely that, as a result of careful design by the manufacturer, the important instrument characteristics affecting column 

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The information contained in the three data bases provides the necessary information required to design the optimum column. In addition, once the column has been designed, and its properties defined, a complementary set of Analytical Specifications can also be calculated. Thus, the design protocol contains three data bases. Performance Criteria, Elective Variables and Instrument Constraints. 

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