Tetrahymena pyriformis growth inhibition

The measured toxicity is represented by the molar concentration that produces a 50% growth inhibition (IGC50) of the protozoan ciliate Tetrahymena pyriformis. The biological activities, A = log(l/IGC5o), together with the values of ovality descriptors 0,0 (i = 1,2,3) are systematized in Table 15.4. 

Geldanamycin inhibited the growth and multiplication of protozoa, being primarily active against Tetrahymena pyriformis and Crithidia fasciculata. It was also active against L-1210 and KB cells growing in culture, and against the parasite Syphacia... 

NRI] assay, Coomassie blue [CB] assay, and cellular growth rate [CGR] assay) to develop QSARs to predict IC50 values, that is, the concentration that inhibited 50% of the L-929 cell line of murine fibroblasts (Table 5.20). In addition, Sauvant et al. (1997) developed a QSAR to predict the IC50 values for the ciliated protozoa, Tetrahymena pyriformis GL, using the doubling time from a T. pyriformis GL population assay or DTP (Table 5.20). 

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