Tetraethylammonium cephalosporins

Cephalosporins such as cephalothin and cephaloridine interact with both the anionic (p-aminohippurate, PAH) and cationic (tetraethylammonium, TEA or N-methybiicotinamid, NMN) transport systems [31, 67, 85]. p-lactams have been shown to be secreted by the S2 segment of the proximal tubule via the PAH transport system [85]. Cephalothin inhibited the transport of PAH in rabbit basolateral and in brush border membrane vesicles [84] while cephaloridine inhibited the transport of PAH and TEA and in rat renal cortical slices [26, 77] and of PAH [77, 84] or NMN [84] in rat brush border membrane vesicles (BBMV). 

Duwe J, Cojocel C, Baumann K. Effect of paraquat-like substances and cephalosporins on accumulation of p-aminohippurate and tetraethylammonium in rat renal cortical slices, and on lipid peroxidation in rat renal microsomes and cortical alices. In Nephrotoxicity. Mechanisms, early diagnosis, and therapeutic management. Bach PH, Gregg NJ, Wilks MF, Delacruz L (editors). Marcel Dekker Inc, New York 1991 p. 13-17. 

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