Tetracyclines description

The tetracycline antibiotic minocycline (Minocin) is modestly effective in the treatment of rheumatoid arthritis and is generally well tolerated. Radiographic evidence of its efficacy as a DMARD is lacking, although clinical symptoms do abate. It can be useful in the treatment of early, mild disease. A more detailed description of the pharmacology and chnical uses of minocycline is found in Chapter 47. 

The first detailed description of the drying of products in spray form was mentioned in a patent of 1872 entitled Improvement of Drying and Concentration of Liquid Substances by Atomizing (2). However, this process found its first significant applications in the milk and detergent industries in the 1920 s (3). In current times, spray drying is utilized extensively in many aspects of our daily life from food products, cosmetics, and pharmaceuticals to chemicals, fabrics, and electronics. Typical pharmaceutical examples include spray-dried enzymes (such as amylase, protease, lipase, and trypsin), antibiotics (such as sulfathiazole, streptomycin, penicillin, and tetracycline) and many other active pharmaceutical ingredients, vitamins (such as ascorbic acid and vitamin B12), and excipients for direct compression (such as lactose, mannitol, and microcrystalline cellulose). 

Antibiotics are metabolites produced by micro-organisms that kill or inhibit other micro-organisms. Only two antibiotics have retained some importance, albeit relatively minor nisin and pimaridn (for details see description above). Three others namely different tetracyclines, subtilin and tylosin have been studied and found effective for various food applications. But these substances have never been widely allowed as a food additive, because substances employed therapeutically shall not be used as food additives. In general antibiotics are prohibited... 

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