Tetracycline, topical application

Fig. 1. Cumulative subjective plus objective symptom score after 10-day topical application of rifaximin (5% cream, n = 30, R) or chlor-tetracycline (3% cream, n = 30, C) of patients with pyogenic skin infections (from Della Marchina et al. [30]).00 p < 0.01 versus basal value (day 0) p < 0.01 between the two groups. 

Topical tetracycline may turn skin yellow but washing removes the solution fabrics may be stained by heavy topical application... 

Topical Antibiotic Monotherapy Localized impetiginized eczema lesions can be treated successfully with topical fusidic acid or mupirocin, whereas topical application of other antibiotics (neomycin as obsolete aminoglycosid, tetracyclines, or polymyxines) should be avoided.84 Especially in children with AD, fusidic acid resistance seems to be a particular problem reflecting the chronicity and the extent of the disease (see Section 30.2.2). 

Treatment has been difficult as the modalities that are useful in acne vulgaris are often ineffective in chloracne. Topical application of retinoic acid (0.005-0.3% concentration) or of tretinoin (Retin-A) gel or cream is of some benefit in controlling comedones, but other topical agents are of little use (Caputo et al. 1988). A combination of tetracycline and short courses of orally administered prednisone helped with severe inflammatory cases. A trial regimen of methotrexate, 25 mg every 10 days for several months was unsuccessful (Taylor et al. 1977). 

Nystatin - An important use of nystatin remains the local treatment of Candida infections topical applications of this antibiotic are recommended for onychomycosis (nail infections). 102 Additional reports have appeared concerning the use of nystatin or hamycin in combination with tetracycline antibiotics in order to suppress Candida overgrowth which can... 

The broad antibacterial activity of rifaximin as well as its topical action make this antibiotic suitable for intrapocket administration in periodontal disease. As a matter of fact, local application of rifaximin compares well with tetracyclines and metronidazole in other extra-GI diseases, i.e. skin infections and BY, respectively (see above). On the other hand, rifampicin (rifampin), another rifamy-cin derivative, has been successfully used in the treatment... 

Local Application Except for local use in the eye, topical use of the tetracyclines is not recommended. Minocychne sustained-release microspheres for subgingival administration are used in dentistry as an adjunct in patients with adult periodontitis. 

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