1,4,7,10-Tetraazacyclododecane l-

Other examples of ancillary ligands used to enhance analyte selectivity include amide-modified D03A (1,4,7,10-tetraazacyclododecane-l,4,7-trisacetate) complexed to Tb , which selectively binds the bidentate analytes p-dimethylaminobenzoic acid (DMABA) and SA (160-162). The binary complex of with EDTA can effectively detect SA, 4-aminosalicylic acid and 5-fluorosalicylic acid (163). [Tb(EDTA)] also has been used to detect catalysis of hydroxybenzoic acid (HBA) by hemin via formation of a ternary complex with the HBA oxidation product (164). Diaza-crown ethers have been utilized with and Eu to detect phthalate, benzoate,... 

A second compound that has been used is Ytterbium tetramethyl-1,4,7,10-tetraazacyclododecane-l,4,7,10-tetraacetic acid (DOTMA) with octa-coordinate bonding of the ligand to Yb via four nitrogen and four oxygen atoms. The twelve equivalent protons of the methyl groups have a resonance at -18 ppm relative to water, and show a temperature dependence of -0.04 0.01 ppmK. The chemical shift difference between the ac and axl proton resonances in the ligand was measured in human serum and found to be linear over a range of 308-318 K with a sensitivity of -0.41 ppmK. ... 

Conjugation of 1,4,7,10-tetraazacyclododecane-l, 4,7,10-tetraacetic acid (DOTA) and its derivatives to peptides, applications, and future prospects of the conjugates 07MRO281. 

AGE, advanced glycation end product CML, A -carboxymethyl-L-lysine DMF, AiV-dimethylformamide DOTA, 1,4,7,10-tetraazacyclododecane-l,4,7,10-tetraacetate DTPA, diethylenetriamine pentaaeetate FAD, flavin adenine dinucleotide FN3K, fiuctosamine-3-kinase GLUTS, glucose transporter-5 GTP, guanidine triphosphate ... 

Synthesis of DOTA-based bifunctional prochelator (4,7,10-tricarboxymethyl-feit-butyl ester 1,4,7,10-tetraazacyclododecane-l-acetate) (Heppeler et al. 1999a)... 

L. Smentek, B. Andes Hess, Jr., H. C. Manning, and D. J. Bornhop, Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-l,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. Journal of Chemical Physics, 123, 244302 (2005). 

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