Tetany pentamidine

PENTAMIDINE ISETIONATE (INTRAVENOUS) FOSCARNET SODIUM Risk of hypocalcaemia Unclear possibly additive hypocalcaemic effects Use extreme caution with intravenous pentamidine monitor serum calcium (correct before the start of treatment), renal function and signs of tetany closely. Stop one drug if necessaiy... 

Another previous report [187] described severe hypocalcemia with tetany in patients with AIDS concomitantly receiving pentamidine and foscarnet. The hypocalcemia, however, was attributed to the administration of foscarnet. Despite magnesium replacement, magnesium wasting may persist up to two months after the discontinuation of pentamidine, suggesting that anatomic renal tubular injury may be responsible [183,185]. Both abnormalities developed within 6 to 10 days of pentamidine administration. Because life-threatening arrhythmias can develop, especially at serum magnesium levels less than 1.6 mg/dl, early replacement therapy is clinically warranted. 

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